2 edition of Study of a transplantable mouse adenocarcinoma of the colon and its effect on the host found in the catalog.
Study of a transplantable mouse adenocarcinoma of the colon and its effect on the host
Sahira Abod Ali
1985 in Bradford .
Written in English
M.Phil. thesis. Typescript.
Antitumour activity is one of the health-promoting effects attributed to the lactic acid bacteria and their products of fermentation. Previous studies in mice demonstrated that bioactive compounds released in milk fermented by Lactobacillus helveticus R contribute to its immunoenhancing and antitumour properties. The aim of the present work was to study the effects of Cited by: Colon cancer is the third most common cancer globally nowadays,1 and its mortality rate ranked third worldwide.1 The incidence of colon cancer is increasing especially in Asia and Eastern Europe.1 Hong Kong, Japan, Singapore, and Taiwan are the 4 places in Asia with comparatively high Downloaded from by guest on June 5, Tetteh PW, Kretzschmar K, Begthel H, Van Den Born M, Korving J, Morsink F et al. Generation of an inducible colon-specific Cre enzyme mouse line for colon cancer research. Proceedings of the National Academy of Sciences of the United States of America. Oct 18;(42)Cited by: Read about cancer signs, stages, cells, symptoms, and types. Learn what cancer is and what causes it. Inform yourself about the role viruses play in contributing to cancer. Learn why cancer occurs and how cancer cells form.
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The tumor was readily transplantable by subcu- taneous, intrasplenic, and intrahepatic inoculation of small fragments, and has taken subcutaneously in over 75 per cent of all C3H mice inoculated, both males and females.
Transplants have grown to 2 cm. in size in from 6 weeks to 6 months. Corbett TH, Griswold DP, Jr, Roberts BJ, Peckham JC, Schabel FM, Jr. Biology and therapeutic response of a mouse mammary adenocarcinoma (16/C) and its potential as a model for surgical adjuvant chemotherapy. Cancer Treat Rep.
;62(10)– PubMed Google ScholarCited by: The mouse adenocarcinoma of the colon (MAC) Accepted 1 March This work was supported by the Whyte Watson/Turner Cancer Research Trust, Bradford, West Yorkshire, U.K.
and by a mini project funded by the Screening and Pharmacology Group of the EORTC. series of transplantable tumours has been shown to have a similar spectrum of histology and chemosensitivity to human large bowel Cited by: The mouse adenocarcinoma of the colon (MAC) system, which has been shown to be a good model for human colorectal carcinoma in terms of its chemosensitivity, was tested with two modified human.
technic was used to study the effect of x-radiation on tumor cells in suspension:first, to establish the lethal effect of equal doses of radiation on different concentrations of tumor cells; second, to deter mine the influence of radiation on the growth pe riod; third, to determine whether any radiation effect would be transmitted to a second transplant.
For many decades, the results from transplantable tumor models have been viewed with considerable skepticism. The perception has long been that these models are excessively sensitive, and not predictive of the human by: The MC38 murine CRC cell line is derived from a grade-III adenocarcinoma that was chemically induced in a female C57BL/6 mouse and used since then as a transplantable mouse tumor model Several studies have shown that the cell line is immunogenic and can be used as a model for investigating anticancer immunity and immunotherapy 15 – Cited by: Its effect on CC, a dimethylhydrazine-induced, transplantable, weakly immunogenic adenocarcinoma of the colon in WAG rats, was studied.
ABPP was found to have no direct cytotoxic effect on CC cells in by: Experimental mouse tumour models have provided key mechanistic insights into host antitumour immune responses, and these have guided the development of novel treatment by: The arsenal of treatments for most cancers fit broadly into the categories of surgery, chemotherapy, radiation, and targeted therapy.
All represent proven and successful strategies, yet each can trigger local (tumor) and systemic (host) processes that elicit unwanted, often opposing, influences on cancer growth. Under certain conditions, nearly all cancer treatments can facilitate metastatic Cited by: Studies in rodents with primary malignancies indicated less of an effect with hydralazine and studies from this laboratory indicated that hydralazine was more effective at shutting down blood supply to a s.c.
transplanted murine colon tumour than to the same tumours transplanted by: As noted above, a study of human breast cancer tissues suggested an important role for host cell-derived MCP-1 in the infiltration of macrophages into tumors.
78 4T1 breast cancer cells were Cited by: led to a signiﬁcantly improved therapeutic effect. This study highlights the importance of the tissue of implan-tation in sculpting the tumor microenvironment.
These are important fundamental issues in tumor biology and crucial factors to consider in the design of experimental models and treatment. The study was done in two transplantable, syngeneic animal models, a murine mammary carcinoma and an anaplastic colon adenocarcinoma in rats (92).
Treatment with oral honey led to a pronounced. Abstract. Although animals bearing the MAC16 colon adenocarcinoma showed progressive weight loss, the average food consumption ( +/- Kcal day-1) did not differ from non tumour-bearing controls ( +/- Kcal day-1), while animals bearing a related colon adenocarcinoma, MAC13, which had no effect on body weight had a significantly (P less than ) elevated food intake ( +/- 0.
In an effort to establish an animal colon tumor model suitable for biological and chemotherapy studies, 82 colon tumors were induced and transplanted in four different inbred strains of mice.
Four colon tumors survived the first transplant and are now in serial passage. All are suitable for chemotherapy by: Beck SA, Tisdale MJ. Production of lipolytic and proteolytic factors by a murine tumor-producing cachexia in the host.
Cancer Res. Nov 15; 47 (22)– Bibby MC, Double JA, Ali SA, Fearon KC, Brennan RA, Tisdale MJ. Characterization of a transplantable adenocarcinoma of the mouse colon producing cachexia in recipient animals.
A critical question was the identity of the major innate immune pathway that detects the presence of tumor cells and/or tumor-derived factors in order to trigger the production of type I IFNs by host APCs.
Mechanistic studies using mouse transplantable tumor models showed that signaling through TLRs, the cytosolic RNA sensing pathway mediated Cited by: Although a number of factors likely contributed to the failure of these trials, one limitation may be the animal models currently used to study cancer cachexia.
Two commonly used mouse models are xenograft colon (C) and Lewis lung carcinoma (LLC)Cited by: Adenocarcinoma is a type of cancer that may affect various organs. It is derived from the word “adeno” meaning 'pertaining to a gland' and “carcinoma” meaning cancer.
Colon Cancer Case Study – Background. U.K. born Dr. Bethany Ballinger is the Program Director for the University of Central Florida College of Medicine (UCF COM) in Florida, USA. Ballinger is also a practising physician at Osceola Regional Medical Center in Kissimmee, Florida, and Associate Professor of Emergency Medicine at the UCF College of Medicine.
BN, a transplantable colon carcinoma induced in a Brown Norway (BN) rat by 1,2-dimethyl-hydrazine. BRDOX produces cures of estab lished s.c. RCA human colon carcinomas in athymic mice and rats.
BRDOX also cured both s.c. and intrahepatic BN tumors in immunocompetent BN rats. Unconjugated DOX, given at its maximumCited by: The genesis of the C26 colon carcinoma model.
Induring an effort to establish an animal colon tumor model for biological and chemotherapy studies, colon tumors were induced and transplanted in different inbred mouse strains.
Four tumors survived the first transplant, which displayed a variety of histological and malignancy by: Colorectal cancer. Colorectal cancer is the 3rd most common type of cancer worldwide with about million new cases diagnosed in accounting for % of all cancers (Ferlay and others ).An increased consumption of milk or dairy products is associated with a significant reduction in colon cancer (Elwood and others ).Cho and others conducted a large pooled analysis of data from 10 Cited by: Lcs has also exhibited a strong anti-tumor effect in mice by regulating the host immune response in a 3-methylcholanthrene [MC]-induced carcinogenesis model [ 63] that has been used to induce many tumors, including colon cancer model [ 64, 65 ].
An LcS oral feeding of mice is likely to counteract MC-induced Cited by: Cancer is a class of diseases in which a group of cells displays uncontrolled growth and invasion that destroys adjacent tissues, and sometimes send metastasis to other locations in the body.
When one is interested in cancer research, mice will be the preferred animal. Murine models of cancer include transplantable models, spontaneous and autochthonous models, human tumor xenografts. International Prospective Observational Cohort Study for Optimal Bowel Resection Extent and Central Radicality for Colon Cancer (T-REX) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators.
-Genetic predisposition - generally doesn't play a big role except for some types like breast and colon cancer% of all cancers are from lifestyle factors. Lung Cancer-Leading cause of caner deaths in the US y study was halted at its midpoint.
-Reducing estrogen production -Precautions needed-Osteoporosis → need Vit D and E in diet. A SCREENING STRATEGY FOR METAL ANTITUMOR AGENTS AS EXEMPLIFIED BY GOLD(Ill) COMPLEXES Simon P.
Fricker AnorMEDInc. #, th Avenue, Langley, BC, V2Y N5, Canada The use of a screening strategy based on human tumor cell lines, which are also tumorigenic in immune-deprived mice, is described. Activity against the human tumor cells in and in vivo, is complemented with studies.
We previously established long-term culture conditions under which single crypts or stem cells derived from mouse small intestine expand over long periods. The expanding crypts undergo multiple crypt fission events, simultaneously generating villus-like epithelial domains that contain all differentiated types of cells.
We have adapted the culture conditions to grow similar epithelial Cited by: The BALB-neuT mouse has proven to be a useful model to study the effects of tumor-released factors on host functions in a more physiologic way than in healthy mice injected with such factors. In fact, BALB-neuT mice provide a model of a progressively “sick” patient where therapy protocols can be adjusted to account for compromised host Cited by: Recently, it has been reported that Andro has another pharmacological effect on inhibiting various common tumors cell proliferation and invasion, including hepatocellular carcinoma, cervical carcinoma, prostatic adenocarcinoma, oral squamous cell carcinoma, gastric cancer, and colon cancer [8, 9, ].
But the cellular responding of Andro was. In another study, resveratrol had no effect on the growth of implanted Lewis lung carcinoma in mice, but it exhibited a clear antimetastatic effect, decreasing both the number and weight of lung metastases. Furthermore, resveratrol and its tetramer heyneanol decreased tumor growth in mouse Lewis lung by: Effects of levamisole on in vivo and in vitro murine host response to syngeneic transplantable tumor Journal Article Fidler, I J ; Spitler, L E - J.
Natl. Cancer Inst., v. 55, no. 5, pp. The effects of levamisole were studied in vivo and in vitro on two murine tumors, B16 melanoma and adenocarcinomasyngeneic to the mouse.
These cancer cells include breast, tongue and colon (26–29). In addition, S. cerevisiae can induce apoptosis in nude mice bearing human breast cancer (30,31) and in Swiss albino mice bearing Ehrlich carcinoma.
Studies have shown that one of the metabolites of yeast, trehalose, exerts anticancer effects when combined with synthetic : Mamdooh Ghoneum, Nariman K. Badr El-Din, Ashraf Z. Mahmoud, Lucilene Tolentino, Deyu Pan, Tahia Ali.
Several studies have, however, been concerned with the importance of the condition of the host tissue to the subsequent growth of a tumor (24, 29, 45, 46).
It is the purpose of this paper to present experimental work that further clarifies the mode of action of radiation on the tumor bed (the tumor bed effect, TBE), in so far as this action Cited by: The present studies were undertaken to investigate the anti proliferative effects of DEX in 3 colon tumor lines (one mouse and 2 human tumor xenografts), a rat mammary tumor line (RAC, in both its syngeneic host and as a xenograft in athymic nude mice).
In vitro studies showed that hochuekkito suppressed the production of IL-6 by THP-1 or RAW macrophage cells, although it did not affect IL-6 production by colon 26 carcinoma cells. These results suggest that hochuekkito inhibits the production of proinflammatory cytokines, particularly IL-6, by host cells such as by: Ashwagandha, also known as Indian ginseng, is a popular Ayurvedic herb and considered a tonic with multiple properties.
In the lab, ashwagandha has been shown to have anti-inflammatory effects and relax the central nervous system in animals. Other experiments suggest it can enhance immune cells and impair or kill cancer cells, but more studies.
An important case study of a 47 year old woman suffering from multiple tumors of the brain showed how important hydrogen medicine will be in the future of medicine and modern oncology.
In my book on Hydrogen Medicine I have already written on using hydrogen for cancer patients. This study sustains what I have written and what I believe, and why all cancer patients would benefit, to on. Interleukin (IL) is a IL-1 family member of cytokines exerting pleiotropic activities.
In the steady-state, IL is expressed in the nucleus of epithelial, endothelial, and fibroblast-like cells acting as a nuclear protein.
In response to tissue damage, infections or necrosis IL is released in the extracellular space, where it functions as an alarmin for the immune by: Sulindac for polyposis of the colon Sulindac for polyposis of the colon Waddell, William R.; Loughry, Richard W.
Four members of a Gardner's syndrome family had rectal and colon polyposis treated with nonsteroid anti‐inflammatory drugs. Three of these patients had had subtotal colectomy and ileoproctostomy and the residual polyps arose in the rectal mucosa. CT26 cells were purchased from the American Type Culture Collection (ATCC).
MC38 is a mouse colon adenocarcinoma line derived from a C57/BL6 mouse, and cells were provided by M. Rescigno (European Institute of Oncology). 4T1 is a spontaneous mammary adenocarcinoma derived from a Balb/c mouse and was purchased from : Alessandro Magrì, Giovanni Germano, Annalisa Lorenzato, Simona Lamba, Rosaria Chilà, Monica Montone.